![Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic? Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?](https://www.researchgate.net/profile/Md-Imteyaz-Alam/post/Why_does_ring_opening_reaction_of_lactones_often_follow_nucleophilic_pathway_and_not_electrophilic/attachment/59d622dcc49f478072e99174/AS%3A272119852666883%401441889836668/image/GVL+ring+opening.jpg)
Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?
![Ring-opening polymerization of a five-membered lactone trans-fused to a cyclohexane ring | Polymer Journal Ring-opening polymerization of a five-membered lactone trans-fused to a cyclohexane ring | Polymer Journal](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fpj.2013.70/MediaObjects/41428_2014_Article_BFpj201370_Figb_HTML.jpg)
Ring-opening polymerization of a five-membered lactone trans-fused to a cyclohexane ring | Polymer Journal
![W(OTf)6‐Catalyzed Synthesis of γ‐Lactones by Ring Contraction of Macrolides or Ring Closing of Terminal Hydroxyfatty Acids in Ionic Liquid - Xie - 2018 - ChemSusChem - Wiley Online Library W(OTf)6‐Catalyzed Synthesis of γ‐Lactones by Ring Contraction of Macrolides or Ring Closing of Terminal Hydroxyfatty Acids in Ionic Liquid - Xie - 2018 - ChemSusChem - Wiley Online Library](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/b33d9a35-93d1-4fa4-90f8-b5dcd543a1dc/cssc201800587-fig-5002-m.jpg)
W(OTf)6‐Catalyzed Synthesis of γ‐Lactones by Ring Contraction of Macrolides or Ring Closing of Terminal Hydroxyfatty Acids in Ionic Liquid - Xie - 2018 - ChemSusChem - Wiley Online Library
![Ring-opening polymerization of γ-lactones and copolymerization with other cyclic monomers - ScienceDirect Ring-opening polymerization of γ-lactones and copolymerization with other cyclic monomers - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0079670020301027-sc5.jpg)
Ring-opening polymerization of γ-lactones and copolymerization with other cyclic monomers - ScienceDirect
![Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic? Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?](https://www.researchgate.net/profile/Eric-Harris-6/post/Why_does_ring_opening_reaction_of_lactones_often_follow_nucleophilic_pathway_and_not_electrophilic/attachment/59d63193c49f478072ea11d1/AS%3A273625876238350%401442248900395/image/lactone+2.jpg)
Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?
![Ring opening polymerization of β-acetoxy-δ-methylvalerolactone, a triacetic acid lactone derivative - ScienceDirect Ring opening polymerization of β-acetoxy-δ-methylvalerolactone, a triacetic acid lactone derivative - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1759995422061411-d1py00561h-ga.jpg)
Ring opening polymerization of β-acetoxy-δ-methylvalerolactone, a triacetic acid lactone derivative - ScienceDirect
![Ring-opening polymerization of a macrocyclic lactone monomer isolated from oligomeric byproducts of poly(butylene succinate) (PBS): An efficient route to high-molecular-weight PBS and block copolymers of PBS - ScienceDirect Ring-opening polymerization of a macrocyclic lactone monomer isolated from oligomeric byproducts of poly(butylene succinate) (PBS): An efficient route to high-molecular-weight PBS and block copolymers of PBS - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0032386114007204-fx1.jpg)
Ring-opening polymerization of a macrocyclic lactone monomer isolated from oligomeric byproducts of poly(butylene succinate) (PBS): An efficient route to high-molecular-weight PBS and block copolymers of PBS - ScienceDirect
![Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies - Engel - 2019 - ChemCatChem - Wiley Online Library Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies - Engel - 2019 - ChemCatChem - Wiley Online Library](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/8f1cbf04-2ed3-4577-8dfd-1f7bde7f97fd/cctc201900976-toc-0001-m.jpg)
Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies - Engel - 2019 - ChemCatChem - Wiley Online Library
![Synthetic schemes of poly(ester) by ring opening polymerization with... | Download Scientific Diagram Synthetic schemes of poly(ester) by ring opening polymerization with... | Download Scientific Diagram](https://www.researchgate.net/profile/Beom-Jin-Lee-4/publication/274579719/figure/fig4/AS:503404244209664@1497032332313/Synthetic-schemes-of-polyester-by-ring-opening-polymerization-with-cyclic-lactones-a.png)
Synthetic schemes of poly(ester) by ring opening polymerization with... | Download Scientific Diagram
Synthesis of poly(disulfide)s with narrow molecular weight distributions via lactone ring-opening polymerization - Chemical Science (RSC Publishing)
![Scheme 8. Ring-opening of a -lactone upon either (a) an oxygenacyl or... | Download Scientific Diagram Scheme 8. Ring-opening of a -lactone upon either (a) an oxygenacyl or... | Download Scientific Diagram](https://www.researchgate.net/profile/Sophie-Guillaume-2/publication/264810943/figure/fig1/AS:613867201773568@1523368754044/Scheme-8-Ring-opening-of-a-lactone-upon-either-a-an-oxygenacyl-or-b-an.png)
Scheme 8. Ring-opening of a -lactone upon either (a) an oxygenacyl or... | Download Scientific Diagram
![Ring-opening polymerization of lactones using supramolecular organocatalysts under simple conditions - RSC Advances (RSC Publishing) DOI:10.1039/C2RA22535B Ring-opening polymerization of lactones using supramolecular organocatalysts under simple conditions - RSC Advances (RSC Publishing) DOI:10.1039/C2RA22535B](https://pubs.rsc.org/image/article/2012/RA/c2ra22535b/c2ra22535b-s2.gif)
Ring-opening polymerization of lactones using supramolecular organocatalysts under simple conditions - RSC Advances (RSC Publishing) DOI:10.1039/C2RA22535B
Ring openings of lactone and ring contractions of lactide by frustrated Lewis pairs - Dalton Transactions (RSC Publishing)
![Ring-opening polymerization of γ-lactones and copolymerization with other cyclic monomers - ScienceDirect Ring-opening polymerization of γ-lactones and copolymerization with other cyclic monomers - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0079670020301027-sc6.jpg)
Ring-opening polymerization of γ-lactones and copolymerization with other cyclic monomers - ScienceDirect
![Controlled Random Terpolymerization of β-Propiolactone, Epoxides, and CO2 via Regioselective Lactone Ring Opening | CCS Chem Controlled Random Terpolymerization of β-Propiolactone, Epoxides, and CO2 via Regioselective Lactone Ring Opening | CCS Chem](https://www.chinesechemsoc.org/cms/asset/21b5eddd-9eda-4bd7-a19d-e32d86c7b740/keyimage.jpg)
Controlled Random Terpolymerization of β-Propiolactone, Epoxides, and CO2 via Regioselective Lactone Ring Opening | CCS Chem
![Completely recyclable biopolymers with linear and cyclic topologies via ring -opening polymerization of γ-butyrolactone | Nature Chemistry Completely recyclable biopolymers with linear and cyclic topologies via ring -opening polymerization of γ-butyrolactone | Nature Chemistry](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnchem.2391/MediaObjects/41557_2016_Article_BFnchem2391_Fig1_HTML.jpg)
Completely recyclable biopolymers with linear and cyclic topologies via ring -opening polymerization of γ-butyrolactone | Nature Chemistry
![Molecules | Free Full-Text | Coordination Ring-Opening Polymerization of Cyclic Esters: A Critical Overview of DFT Modeling and Visualization of the Reaction Mechanisms Molecules | Free Full-Text | Coordination Ring-Opening Polymerization of Cyclic Esters: A Critical Overview of DFT Modeling and Visualization of the Reaction Mechanisms](https://www.mdpi.com/molecules/molecules-24-04117/article_deploy/html/images/molecules-24-04117-ag-550.jpg)
Molecules | Free Full-Text | Coordination Ring-Opening Polymerization of Cyclic Esters: A Critical Overview of DFT Modeling and Visualization of the Reaction Mechanisms
![Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic? Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?](https://www.researchgate.net/profile/Md-Imteyaz-Alam/post/Why_does_ring_opening_reaction_of_lactones_often_follow_nucleophilic_pathway_and_not_electrophilic/attachment/59d62923c49f478072e9c151/AS%3A272467027791893%401441972609852/download/El+RO1.jpg)